GLP-1 medications are changing how millions approach weight loss — but the options, costs, and clinical realities can be overwhelming. We break it all down, simply and honestly.
GLP-1 stands for glucagon-like peptide-1 — a hormone your body naturally produces after eating. It signals your brain that you're full, slows digestion, and helps regulate blood sugar.
GLP-1 receptor agonists are medications that mimic this hormone but much more powerfully and for much longer. The result: significantly reduced appetite and meaningful, sustained weight loss.
Read the full GLP-1 guideAverage body weight lost with semaglutide over 68 weeks in clinical trials
Average weight loss with tirzepatide (Zepbound) — the strongest option available
Americans currently using a GLP-1 medication for weight management
Lowest monthly cost through telehealth programs using compounded semaglutide
FDA-approved for weight loss. Trials show ~15% body weight reduction on average.
FDA-Approved · Weight LossSame ingredient as Wegovy, approved for Type 2 diabetes. Widely prescribed off-label for weight loss.
Off-Label Weight UseNewest FDA-approved option. Dual GIP/GLP-1 mechanism showing up to 22% body weight loss.
Strongest ResultsSame active ingredient, 30–60% cheaper. Used by most telehealth programs to keep costs down.
Most AffordableWe've broken down every major GLP-1 telehealth program on cost, medication type, clinical support, and what's included.
A short intake form about your health history and weight goals. Takes 5–10 minutes online.
A doctor or NP reviews your intake and determines if GLP-1 therapy is appropriate for you.
If approved, your prescription ships to you within days. Monthly check-ins adjust your dose.
See all programs side by side — pricing, support, and what's included.
Medical Disclaimer: WeightShots.com is an informational website only. We do not provide medical advice, diagnosis, or treatment. Always consult a qualified healthcare professional before starting any medication. Affiliate Disclosure: We earn a commission when you sign up through our links, at no extra cost to you.